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Huntington Medical Research Institutes
Huntington Medical Research Institutes (HMRI) is an independent, nonprofit, applied medical research organization in Pasadena, California. The Institutes conduct laboratory and clinical work for the development of technology used in the diagnosis and treatment of disease. The Molecular Medicine programs, such as cancer genetics, molecular neurology, molecular pathology and tissue engineering, are conducted at the 99 North El Molino Avenue facility. The Neural Engineering program is conducted at the 734 Fairmount Avenue building directly adjacent to Huntington Hospital. The Advanced Imaging Laboratory is located nearby at 10 Pico Street, as is the Liver Center at 660 South Fair Oaks Avenue. Marie Csete MD PhD is the President and Chief Scientist.
== Cellular and Molecular Medicine ==
The original organization of HMRI was established in 1952.〔Becky Oskin, Marking 50 Years of Health Research, Pasadena Star-News (Pasadena, California) December 3, 2002〕 The El Molino Avenue laboratory began as the Pasadena Foundation for Medical Research, which placed emphasis on cancer research. Projects included pioneering work with the biomedical research application of laser energy,〔Michael W. Berns and Donald E. Rounds. "Cell surgery by laser." Scientific American 222(3): 98-103(February 1970).〕〔Berns, M. W., Y. Ohnuki, D. E. Rounds, and R. S. Olson. "Modification of nucleolar expression following laser micro-irradiation of chromosomes." Experimental Cell Research 60, no. 1 (1970): 133-138.〕 and in their cell culture laboratory they had developed a now widely used line of prostate cancer cells.〔Kaighn, M. E., K. Shankar Narayan, Y. Ohnuki, J. F. Lechner, and L. W. Jones. "Establishment and characterization of a human prostatic carcinoma cell line (PC-3)." Investigative urology 17, no. 1 (1979): 16.〕 Current work includes the study of protein abnormalities underlying susceptibility to migraine headaches,〔"Dysfunction of Sodium Homeostasis in a Rat Migraine Model" (5R01NS072497). NIH Research Portfolio Online Reporting Tools (RePORT). Retrieved May 11, 2013.()〕 and the development of "histoid" tumor models.〔Mehta, Geeta, Amy Y Hsiao, Marylou Ingram, Gary D Luker, and Shuichi Takayama. "Opportunities and Challenges for Use of Tumor Spheroids as Models to Test Drug Delivery and Efficacy." Journal of Controlled Release (2012).()〕
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